Autophagic cell death induced by resveratrol depends on the Ca2+/AMPK/mTOR pathway in A549 cells
J Zhang, JF Chiu, H Zhang, T Qi, Q Tang, K Ma… - Biochemical …, 2013 - Elsevier
Resveratrol has many biological effects, including anti-tumor, antiviral activities, and
vascular protection. Recent studies have suggested that resveratrol exert its antitumor
effects through induction of autophagy by an unknown mechanism. In this study, we
investigated the involvement of autophagy in resveratrol-induced cell death and its potential
molecular mechanisms in A549 human lung adnocarcinoma cells. Resveratrol-induced
growth inhibition and cell death was assessed by MTT and clonogenic assays. Activation of …
vascular protection. Recent studies have suggested that resveratrol exert its antitumor
effects through induction of autophagy by an unknown mechanism. In this study, we
investigated the involvement of autophagy in resveratrol-induced cell death and its potential
molecular mechanisms in A549 human lung adnocarcinoma cells. Resveratrol-induced
growth inhibition and cell death was assessed by MTT and clonogenic assays. Activation of …
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